## Description

This track displays the p-values (-log10) of the bipolar disorder pooled data as reported by the NIMH Genetics Initiative Bipolar Disorder Consortium (see References below). The Consortium performed a genome-wide asociation study on two populations:

- US (European Descent) — 461 cases in 7 pools, 563 controls in 9 pools
- German — 772 cases in 13 pools, 876 controls in 10 pools

## Methods

Reported p-values were taken for each of the Illumina550 probes on the genome. For visualization purposes, these p-values were logged and negated. These p-values have not been Bonferroni adjusted.

All of the people in the US population had an affected sibling. 96% of the people in the German sample reported that both parents and grandparents were born in Germany. The German sample was used to replicate the US sample. The following conditions were applied to the US sample:

- pval < 0.05
- Odds Ratio > 1.4 or < 0.71
- Relative Allele Frequency > 0.05, required to be near a known gene
- replicated in the German sample with pval < 0.05

The results left 88 SNPs in 80 genes.

When individually genotyped, 76% remained significant in the US sample, and 36% of those remained significant in the German sample. Combined p-values were also calculated for the SNPs yielding the most significant find rs1012053 p-value = 1.5e-8 for the gene DGKH diacylglyceral kinase, which is still significant after Bonferroni adjustment. DGKH protein is key in the lithium-sensitive phosphatidyl inositol pathway. Several other risk SNPs were identified of small effect.

For the complete dataset, visit The National Instututes of Mental Health (NIMH) MAP Genetics Web Site.

## References

Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nothen MM et al. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Molecular Psychiatry. 2007 May 8;:1-11.

In addition, those using data from the NIMH sample should cite the NIMH Genetics Initiative Bipolar Disorder Consortium by use of the language specified in the Distribution Agreement from the NIMH Center for Collaborative Genetic Studies.