## Overview

This super-track combines related tracks of ChIP-chip data generated by the ENCODE group at the Sanger Institute. ChIP-chip, also known as genome-wide location analysis, is a technique for isolation and identification of DNA sequences bound by specific proteins in cells, including histones. Histone methylation and acetylation serves as a stable genomic imprint that regulates gene expression and other epigenetic phenomena. These histones are found in transcriptionally active domains called euchromatin.

These tracks contain ChIP-chip data for H3 and H4 histones in multiple cell lines, including HeLa (cervical carcinoma), GM06990 (lymphoblastoid), K562 (myeloid leukemia), and HFL-1 (embryonic lung fibroblast). Experiments were conducted with antibodies to histones with different post-translational modification marks. Data are displayed as signals as well as hits and peak centers identified by hidden Markov model (HMM) analysis.

## Credits

The data were generated by the ENCODE investigators at the Wellcome Trust Sanger Institute, Hinxton, UK. Contacts: Ian Dunham and Christoph Koch.

The HMM analysis was performed at the EBI by Paul Flicek.

Raw data may be downloaded from the Sanger Institute website at ftp://ftp.sanger.ac.uk/pub/encode.