## Description

This track shows sequence annotation curated at The Welcome Trust Sanger Institute.

Over 10% of the human genome, including two complete chromosomes — 20 and 22 — have been annotated by the sequence annotation team in collaboration with the individual chromosome project teams.

NOTE: Sanger20 annotations appear only on chromosome 20.

## Methods

Finished genomic sequence is analyzed on a clone by clone basis using a combination of similarity searches against DNA and protein databases as well as a series of ab initio gene predictions (Genscan, Fgenesh). Gene structures are annotated on the basis of human interpretation of the combined supportive evidence generated during sequence analysis. In parallel, experimental methods are applied to extend incomplete gene structures and discover new genes. The latter is initiated by comparative analysis of the finished sequence with vertebrate datasets such as the Riken mouse cDNAs, mouse whole-genome shotgun data and GenescopeTetraodon Ecores.

## Credits

Thanks to the Sanger Institute for providing this data set. Email inquiries may be sent to humquery@sanger.ac.uk.