## Description

This track shows 81 regions detected as putative copy number polymorphisms by representational oligonucleotide microarray analysis (ROMA) in a population of 20 normal individuals.

## Methods

Following digestion of with BglII or HindIII, genomic DNA was hybridized to a custom array consisting of 85,000 oligonucleotide probes, probes were selected to be free of common repeats and have unique homology within the human genome. The average resolution of the array is ~35 kb, however only intervals in which 3 consecutive probes showed concordant signal were scored as CNPs. All hybridizations were performed in duplicate incorporating a dye-reversal, with the false positive rate estimated to be ~6%.
Note that CNP intervals as detailed by Sebat et al. (2004) were converted from the April 2003 (build33) into the July 2003 (build34) assembly using liftover.

## References

Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, Maner S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, Reiner A, Gilliam TC, Trask B, Patterson N, Zetterberg A, Wigler M (2004) Large-Scale Copy Number Polymorphism in the Human Genome. Science 305:525-528