### Description

This column shows the Gladstone H-value overall specificity score for a gene based on its expression.

### Methods

The H-value and Q-value were both calculated based on expression of probes on a GNF microarray. These probes are associated to genes by aligning the probe set to the genome. Based on the expression of a gene on the microarray, Shannon entropy calculations yield scores for each gene's specificity to a certain tissue (the Q-value) and its overall specificity (H-value). In the case of the Q-value, only the lowest value is shown, corresponding to the tissue to which the gene has the highest specificity.

For detailed information about the H-value, Q-value, and Shannon entropy, see: Schug, J. et al. Promoter features related to tissue specificity as measured by Shannon entropy. Genome Biol. 13(6), 601-608 (2005).

### Credits

The data for this column were kindly provided by the Bruce Conklin lab at the Gladstone Institute at UCSF.