## Overview

This super-track combines related tracks from the Genome Institute of Singapore. These tracks show transcriptome and protein binding sites as determined by paired-end ditag (PET) sequencing. Experiments were performed in a variety of cell lines, including MCF7 (breast adenocarcinoma), HCT116 (colon epithelial carcinoma), HeLa (cervical carcinoma), hES3 (embryonic stem), and P493 (B cell), with various treatments, including estrogen, 5-flourouracil, and gamma interferon. Binding sites are displayed for multiple transcription factors and histone modifications, including p53, STAT1, c-Myc, H3K4me3 and H3K27me3,

## Credits

The GIS-PET libraries and sequence data were produced at the Genome Institute of Singapore. The data were mapped and analyzed by scientists from the Genome Institute of Singapore and the Bioinformatics Institute of Singapore.

## References

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Ng P, Wei CL, Sung WK, Chiu KP, Lipovich L, Ang CC, Gupta S, Shahab A, Ridwan A, Wong CH, et al. Gene identification signature (GIS) analysis for transcriptome characterization and genome annotation. Nat Methods. 2005 Feb;2(2):105-11.

Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z et al. A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome. Cell. 2006 Jan 13;124(1):207-19.

Chiu KP, Wong CH, Chen Q, Ariyaratne P, Ooi HS, Wei CL, Sung WK, Ruan Y. PET-Tool: a software suite for comprehensive processing and managing of Paired-End diTag (PET) sequence data. BMC Bioinformatics. 2006 Aug 25;7:390.

Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT, Ooi HS, Orlov YL, Shahab A, Yong HC et al. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17834-9.