phenoModel               package:nlme               R Documentation

Model function for the Phenobarb data

Description:

     A model function for a model used with the 'Phenobarb' data. This
     function uses compiled C code to improve execution speed.

Usage:

     phenoModel(Subject, time, dose, lCl, lV)

Arguments:

 Subject: an integer vector of subject identifiers.  These should be
          sorted in increasing order.

    time: numeric. A vector of the times at which the sample was drawn
          or the drug administered (hr). 

    dose: numeric. A vector of doses of drug administered (mug/kg). 

     lCl: numeric.  A vector of values of the natural log of the
          clearance parameter according to 'Subject' and 'time'.

      lV: numeric.  A vector of values of the natural log of the
          effective volume of distribution according to 'Subject' and
          'time'.

Details:

     See the details section of 'Phenobarb' for a description of the
     model function that 'phenoModel' evaluates.

Value:

     a numeric vector of predicted phenobarbital concentrations.

Author(s):

     Jose Pinheiro jose.pinheiro@pharma.novartis.com and Douglas Bates
     bates@stat.wisc.edu

References:

     Pinheiro, J. C. and Bates, D. M. (2000) _Mixed-effects Models in S
     and S-PLUS_, Springer. (section 6.4)

