aml                   package:boot                   R Documentation

Remission Times for Acute Myelogenous Leukaemia

Description:

     The 'aml' data frame has 23 rows and 3 columns.

     A clinical trial to evaluate the efficacy of maintenance
     chemotherapy for acute myelogenous leukaemia was  conducted by
     Embury et al. (1977) at Stanford University.  After reaching a
     stage of remission through treatment by chemotherapy, patients
     were randomized into two groups. The first group received
     maintenance chemotherapy and the  second group did not.  The aim
     of the study was to see if maintenance  chemotherapy increased the
     length of the remission.  The data here formed a preliminary
     analysis which was conducted in October 1974.

Usage:

     aml

Format:

     This data frame contains the following columns:


     'time' The length of the complete remission (in weeks).

     'cens' An indicator of right censoring.  1 indicates that the
          patient had a relapse and so 'time' is the length of the
          remission. 0 indicates that the patient had left the study or
          was still in remission in October 1974, that is the length of
          remission is right-censored.

     'group' The group into which the patient was randomized.  Group 1
          received maintenance chemotherapy, group 2 did not.

Note:

     Package 'survival' also has a dataset 'aml'. It is the same data
     with different names and with 'group' replaced by a factor 'x'.

Source:

     The data were obtained from

     Miller, R.G. (1981) _Survival Analysis_. John Wiley.

References:

     Davison, A.C. and Hinkley, D.V. (1997)  _Bootstrap Methods and
     Their Application_. Cambridge University Press.

     Embury, S.H, Elias, L., Heller, P.H., Hood, C.E., Greenberg, P.L.
     and Schrier, S.L. (1977) Remission maintenance therapy in  acute
     myelogenous leukaemia. _Western Journal of Medicine_, *126*,
     267-272.

