Rabbit                 package:MASS                 R Documentation

Blood Pressure in Rabbits

Description:

     Five rabbits were studied on two occasions, after treatment with
     saline (control) and after treatment with the 5-HT_3 antagonist
     MDL 72222.  After each treatment ascending doses of
     phenylbiguanide were injected intravenously at 10 minute intervals
     and the responses of mean blood pressure measured.  The goal was
     to test whether the cardiogenic chemoreflex elicited by
     phenylbiguanide depends on the activation of 5-HT_3 receptors.

Usage:

     Rabbit

Format:

     This data frame contains 60 rows and the following variables:

     'BPchange' change in blood pressure relative to the start of the
          experiment.

     'Dose' dose of Phenylbiguanide in micrograms.

     'Run' label of run ('"C1"' to '"C5"', then '"M1"' to '"M5"').

     'Treatment' placebo or the 5-HT_3 antagonist MDL 72222.

     'Animal' label of animal used ('"R1"' to '"R5"').


Source:

     J. Ludbrook (1994) Repeated measurements and multiple comparisons
     in cardiovascular research. _Cardiovascular Research_ *28*,
     303-311.
      [The numerical data are not in the paper but were supplied by
     Professor Ludbrook]

References:

     Venables, W. N. and Ripley, B. D. (2002) _Modern Applied
     Statistics with S._ Fourth edition.  Springer.

